| Pair Name | Resveratrol, ABT-737 | ||
| Phytochemical Name | Resveratrol (PubChem CID: 445154 ) | ||
| Anticancer drug Name | ABT-737 (PubChem CID: 11228183 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Resveratrol, ABT-737 | |||
| Disease Info | [ICD-11: 2B33.3] | Acute lymphoblastic leukemia | Investigative | |
| Biological Phenomena | Induction-->DNA damage | |||
| Gene Regulation | Up-regulation | Expression | BAX | hsa581 |
| Down-regulation | Expression | BCL2 | hsa596 | |
| Up-regulation | Expression | TP53 | hsa7157 | |
| In Vitro Model | MOLT-4 | Adult T acute lymphoblastic leukemia | Homo sapiens (Human) | CVCL_0013 |
| Result | The obtained data indicate that the combination of ABT-737 and resveratrol is a promising approach for acute lymphoblastic leukemia treatment that should be further explored. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Combination of ABT-737 and resveratrol enhances DNA damage and apoptosis in human T-cell acute lymphoblastic leukemia MOLT-4 cells. Toxicol In Vitro. 2017 Aug;42:38-46. doi: 10.1016/j.tiv.2017.03.013. | Click |
